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J Vet Sci 2018; 19(4): 577-581  https://doi.org/10.4142/jvs.2018.19.4.577
Isolation and characterization of Korean porcine deltacoronavirus strain KNU16-07
Guehwan Jang1,†, Seong-Hee Kim2,†, Yoo Jin Lee1, Seungjoon Kim3, Du Sik Lee4, Kyoung-Ki Lee2,*, Changhee Lee1,*
1Animal Virology Laboratory, School of Life Sciences, BK21 Plus KNU Creative BioResearch Group, Kyungpook National University, Daegu 41566, Korea
2Animal Disease Diagnostic Division, Animal and Plant Quarantine Agency, Gimcheon 39660, Korea
3College of Veterinary Medicine, Kyungpook National University, Daegu 41566, Korea
4College of Veterinary Medicine, Jeju National University, Jeju 63243, Korea
Correspondence to: Tel: +82-53-950-7365; Fax: +82-53-955-5522; E-mails: changhee@knu.ac.kr (C Lee), naturelkk@korea.kr (KK Lee)
The first two authors contributed equally to this work.
Received: March 30, 2018; Revised: April 13, 2018; Accepted: April 23, 2018; Published online: July 31, 2018.
Porcine deltacoronavirus (PDCoV) has emerged in several pig-raising countries and has been a causative pathogen associated with diarrheal diseases in South Korea since 2014. In the present study, we were able to isolate and cultivate a Korean PDCoV strain (KNU16-07) in cell culture and investigate its pathogenicity. PDCoV-inoculated piglets showed watery diarrhea accompanied by acute enteritis in the natural host. Sequencing analysis demonstrated the genetic stability of KNU16-07 for at least thirty serial passages.
Keywords: cell culture isolation, genome analysis, porcine deltacoronavirus, virulence

© 2018 The Korean Society of Veterinary Science.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.