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Evaluation of renal injury caused by acute volume replacement with Hydroxyethyl Starch 130/0.4 or Ringer’s lactate solution in pigs
David A. Ferreira1, Rita Cruz2, Carlos Venâncio3, Ana I. Faustino-Rocha3,*, Aura Silva4, João R. Mesquita2, Ana Liza Ortiz5, Helena Vala2,3
1Department of Veterinary Medicine, ICAAM Research Center, University of Évora, Évora, Portugal
2Educational, Technologies and Health Study Center (CI&DETS), Polytechnic Institute of Viseu, Viseu, Portugal
3Centre for the Research and Technology of Agro-Environmental and Biological Sciences (CITAB), University of Trás-os-Montes and Alto Douro, Vila Real, Portugal
4REQUIMTE - Faculty of Pharmacy, University of Porto, Porto, Portugal
5Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom
Correspondence to: Tel: +351259350000; Fax: +351259350480; E-mail: anafaustino.faustino@sapo.pt
Received: April 3, 2018; Revised: June 21, 2018; Accepted: July 13, 2018; Published online: July 20, 2018.
This work aimed to evaluate the effects on renal tissue integrity after Hydroxyethyl starch (HES) 130/0.4 and Ringer’s lactate (RL) administration in pigs under general anesthesia after acute bleeding. A total of 30 mL/kg of blood were passively removed from the femoral artery in two groups of Large White pigs, under total intravenous anesthesia with propofol and remifentanil. After bleeding, Group 1 (n=11) received RL solution (25 mL/kg) and Group 2 (n=11) received HES 130/0.4 solution (20 mL/kg). An additional Group 3 (n=6) was not submitted to bleeding or volume replacement. Pigs were euthanized and kidneys were processed for histopathological and immunohistochemical analysis. Minimal to moderate glomerular, tubular and interstitial changes, and papillary necrosis were observed in all experimental groups. Pre-apoptosis and apoptosis indicators were higher in pigs that have received HES 130/0.4, indicating a higher renal insult. Both HES 130/0.4 and RL administration may cause renal injury, although renal injury may be more significant in pigs receiving HES 13/0.4. Results also suggest that total intravenous anesthesia with propofol and remifentanil may cause renal injury, and this can be dose related.
Keywords: Apoptosis, Hemorrhage, Renal injury

© 2018 The Korean Society of Veterinary Science.