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Correlation of SPINK1 gene polymorphisms in canine pancreatitis
Ming-Huei Fan1,2, Shih-Jen Chou1,2, Zhi-Jia Zheng1,2, Jui-Te Wu1,2, Kun-Wei Chan1,2,*
1Graduate Institute and Department of Veterinary Medicine, National Chiayi University. Chiayi City 600, Taiwan
2College of Agriculture Veterinary Teaching Hospital, National Chiayi University, Chiayi City 600, Taiwan
Correspondence to: Tel: +886-5-2732940; Fax: +886-5-2732917; E-mail: kwchan@mail.ncyu.edu.tw
Received: April 3, 2018; Revised: July 5, 2018; Accepted: July 30, 2018; Published online: August 30, 2018.
Abstract
Pancreatitis is an exocrine pancreatic disease in dogs caused by inflammatory injury. The congenital factors and pathogenesis of pancreatitis is not clearly understood. We screened the canine PRSS1 gene in 34 dogs (27 dogs clinically diagnosed with pancreatitis and 7 dogs without pancreatitis as controls), and screened SPINK1 gene in 46 dogs (29 case dogs and 17 control dogs). Serum triglyceride (TG) concentrations were examined between two groups to study the correlation among gene polymorphisms, hypertriglyceridemia (HTG) and canine pancreatitis. Two nucleotide variations were identified in SPINK1 gene: c.60C>A and c.74A>C. There was no correlation between genotype and HTG (P > 0.1). These two variations could be associated with pancreatitis in dogs (P < 0.1). In the recessive model, the case group had a significantly higher proportion of dogs with the homozygous mutation (P < 0.05). In the multiplicative models, the case group had a significantly higher variant allele frequency than the control group (P < 0.05). In this study, common risk factors, such as diet, overweight, and serum TG concentrations were not statistically significant between the cases and controls. However, higher frequency of SPINK1 gene polymorphism indicated a higher risk of pancreatitis in dogs was found.
Keywords: Hypertriglyceridemia; Pancreatitis; PRSS1; SPINK1


© 2018 The Korean Society of Veterinary Science.