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J Vet Sci 2018; 19(5): 708-715  https://doi.org/10.4142/jvs.2018.19.5.708
Bee venom stimulation of a lung meridian acupoint reduces inflammation in carrageenan-induced pleurisy: an alternative therapeutic approach for respiratory inflammation
Hoon-Seong Choi1, Suk-Yun Kang2, Dae-Hyun Roh3, Sheu-Ran Choi1, Yeonhee Ryu2,*, Jang-Hern Lee1,*
1Department of Veterinary Physiology, BK21 PLUS Program for Creative Veterinary Science Research, Research Institute for Veterinary Science and College of Veterinary Medicine, Seoul National University, Seoul 08826, Korea
2KM Fundamental Research Division, Korea Institute of Oriental Medicine, Daejeon 34054, Korea
3Department of Oral Physiology, School of Dentistry, Kyung Hee University, Seoul 02447, Korea
Correspondence to: Tel: +82-2-880-1272; Fax: +82-2-885-2732; E-mails: yhryu@kiom.re.kr (Y Ryu), jhl1101@snu.ac.kr (JH Lee)
Received: February 21, 2018; Revised: May 30, 2018; Accepted: June 4, 2018; Published online: September 30, 2018.
Respiratory inflammation is a frequent and fatal pathologic state encountered in veterinary medicine. Although diluted bee venom (dBV) has potent anti-inflammatory effects, the clinical use of dBV is limited to several chronic inflammatory diseases. The present study was designed to propose an acupoint dBV treatment as a novel therapeutic strategy for respiratory inflammatory disease. Experimental pleurisy was induced by injection of carrageenan into the left pleural space in mouse. The dBV was injected into a specific lung meridian acupoint (LU-5) or into an arbitrary non-acupoint located near the midline of the back in mouse. The inflammatory responses were evaluated by analyzing inflammatory indicators in pleural exudate. The dBV injection into the LU-5 acupoint significantly suppressed the carrageenan-induced increase of pleural exudate volume, leukocyte accumulation, and myeloperoxidase activity. Moreover, dBV acupoint treatment effectively inhibited the production of interleukin 1 beta, but not tumor necrosis factor alpha in the pleural exudate. On the other hand, dBV treatment at non-acupoint did not inhibit the inflammatory responses in carrageenan-induced pleurisy. The present results demonstrate that dBV stimulation in the LU-5 lung meridian acupoint can produce significant anti-inflammatory effects on carrageenan-induced pleurisy suggesting that dBV acupuncture may be a promising alternative medicine therapy for respiratory inflammatory diseases.
Keywords: acupuncture, anti-inflammation, bee venoms, carrageenan-induced pleurisy

© 2018 The Korean Society of Veterinary Science.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.