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Benefits of procyanidins on gut microbiota in Bama minipigs and implications in replacing of antibiotic
Tingting Zhao, Xiaojuan Shen, Chang Dai, Li Cui*
Key Laboratory of Veterinary Biotechnology, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China
Correspondence to: Tel: +86-21-3420692; E-mail: lcui@sjtu.edu.cn
Received: July 19, 2018; Revised: September 16, 2018; Accepted: September 21, 2018; Published online: October 8, 2018.
Abstract
Several studies have reported the effect of absorption of procyanidins and their contribution to small intestine. However, the differences of dietary interventions of procyanidins compared with antibiotic feeding in pigs are rare reported. After 16S rRNA gene Illumina MiSeq sequencing, we found that procyanidin administration for 2 months (procyanidin 1 group) or continuously antibiotics feeding for 1 month and then procyanidin for 1 month (procyanidin 2 group) could increase the number of OTUs, Chao 1 and ACE index compared with antibiotic administration for 2 months (antibiotic group). The genus Fibrobacter and Spirochaete were more abundant in the antibiotic group than those in the procyanidin 1 and procyanidin 2 group. Principal component analysis revealed a clear separation among the three groups. Additionally, using the online MENA pipeline, three co-occurrence network was constructed, and Lactobacillus was co-occurrence with Trichococcus and Desulfovibrio and co-exclusion with Bacillis and Spharerochaeta. Furthermore, metabolic function analysis by PICRUSt demonstrated that modulation of pathways involved in carbohydrate metabolism, amino acid metabolism, energy metabolism, and nucleotide metabolism. These data suggest that procyanidin influences the gut microbiota and the intestinal metabolic function to produce beneficial effects on metabolic homeostasis.
Keywords: procyanidin, gut microbiota, Illumina MiSeq, metabolic function,pig


© 2018 The Korean Society of Veterinary Science.