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J Vet Sci 2018; 19(6): 788-797  https://doi.org/10.4142/jvs.2018.19.6.788
Synergistic effect of ribavirin and vaccine for protection during early infection stage of foot-and-mouth disease
Joo-Hyung Choi1,†, Kwiwan Jeong2,†, Su-Mi Kim1, Mi-Kyeong Ko1, Su-Hwa You1, Young S. Lyoo3, Byounghan Kim1, Jin-Mo Ku2,*, Jong-Hyeon Park1,*
1Animal and Plant Quarantine Agency, Gimcheon 39660, Korea
2Bio-Center, Gyeonggi Business & Science Accelerator, Suwon 16229, Korea
3College of Veterinary Medicine, Konkuk University, Seoul 05029, Korea
Correspondence to: Tel: +82-54-912-0906; Fax: +82-54-912-0890; E-mails: parkjhvet@korea.kr (JH Park), medichem@gbsa.or.kr (JM Ku)
The first two authors contributed equally to this work.
Received: June 19, 2018; Revised: September 3, 2018; Accepted: September 17, 2018; Published online: November 30, 2018.
Abstract
In many countries, vaccines are used for the prevention of foot-and-mouth disease (FMD). However, because there is no protection against FMD immediately after vaccination, research and development on antiviral agents is being conducted to induce protection until immunological competence is produced. This study tested whether well-known chemicals used as RNA virus treatment agents had inhibitory effects on FMD viruses (FMDVs) and demonstrated that ribavirin showed antiviral effects against FMDV in vitro/in vivo. In addition, it was observed that combining the administration of the antiviral agents orally and complementary therapy with vaccines synergistically enhanced antiviral activity and preserved the survival rate and body weight in the experimental animals. Antiviral agents mixed with an adjuvant were inoculated intramuscularly along with the vaccines, thereby inhibiting virus replication after injection and verifying that it was possible to induce early protection against viral infection prior to immunity being achieved through the vaccine. Finally, pigs treated with antiviral agents and vaccines showed no clinical signs and had low virus excretion. Based on these results, it is expected that this combined approach could be a therapeutic and preventive treatment for early protection against FMD.
Keywords: foot-and-mouth disease, ribavirin, vaccine


© 2018 The Korean Society of Veterinary Science.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.