J. Vet. Sci. 2010; 11(1): 35-41  http://dx.doi.org/10.4142/jvs.2010.11.1.35
Effect of German chamomile oil application on alleviating atopic
dermatitis-like immune alterations in mice
Soon-Hee Lee1, Yong Heo2, Young-Chul Kim3,*
1Department of Beauty Art, Howon University, Gunsan 573-718, Korea
2Department of Occupational Health, Catholic University of Daegu, Gyeongsan 712-702, Korea
3Department of Public Health, Keimyung University, Daegu 704-701, Korea
Historically, German chamomile (GC) oil has been used for
treatment of skin disorders. BALB/c mice were sensitized
twice a week with 100 μL of 1% 2,4-dinitrochlorobenzene
(DNCB) and challenged twice the following week with 100 μL
of 0.2% DNCB for atopic dermatitis induction. Thereafter,
3% GC oil was applied daily (70 μL, 6 times week) on the
dorsal skin for 4 weeks. Saline or jojoba oil was used for
the control mice. Blood was collected after second DNCB
challenge, and at 2 and 4 weeks after initiating oil application.
Serum IgE levels were significantly lowered in the GC oil
application group at the end of the 4-week application period.
The GC oil application for 4 weeks resulted in reduction
in serum IgG1 level compared with that after 2-week
application. The GC oil application group showed a
significantly lower serum histamine level than the control
group 2 weeks after oil application. Scratching frequency
of the GC oil application group was significantly lower
than either control groups. This study is to demonstrate
GC oil’s immunoregulatory potential for alleviating atopic
dermatitis through influencing of Th2 cell activation.
Keywords: atopic dermatitis, cytokine, German chamomile oil,
IgE, mice

© 2010 The Korean Society of Veterinary Science.