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JOURNAL OF VETERINARY SCIENCE 13(4): 385~393
Genetic populations of Bacillus anthracis isolates from Korea
Kyoung Hwa Jung
, Sang Hoon Kim
, Se Kye Kim
, Soo Young Cho
, Jin Choul Chai
, Young Seek Lee
, Ji Cheon Kim
, Seoung Joo Kim
, Hee-Bok Oh
, Young Gyu Chai
Institute of Natural Science and Technology, and
Division of Molecular and Life Sciences, Hanyang University, Ansan 426-791, Korea
Department of Bacteriology, National Institute of Health, Cheongwon 363-951, Korea
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (
) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Bacillus (B.) anthracis is the pathogen that causes fatal anthrax. Strain-specific detection of this bacterium using molecular approaches has enhanced our knowledge of microbial population genetics. In the present study, we employed molecular approaches including multiple-locus variable-number tandem repeat analysis (MLVA) and canonical single-nucleotide polymorphism (canSNP) analysis to perform molecular typing of B. anthracis strains isolated in Korea. According to the MLVA, 17 B. anthracis isolates were classified into A3a, A3b, and B1 clusters. The canSNP analyses subdivided the B. anthracis isolates into two of the three previously recognized major lineages (A and B). B. anthracis isolates from Korea were found to belong to four canSNP sub-groups (B.Br.001/2, A.Br.005/006, A.Br.001/002, and A.Br.Ames). The A.Br.001/002 and A.Br.Ames sub-lineages are closely related genotypes frequently found in central Asia and most isolates were. On the other hand, B. anthracis CH isolates were analyzed that belonged to the B.Br.001/002 sub-group which found in southern Africa, Europe and California (USA). B.Br.001/002 genotype is new lineage of B. anthracis in Korea that was not found before. This discovery will be helpful for the creation of marker systems and might be the result of human activity through the development of agriculture and increased international trade in Korea.
: Bacillus anthracis, canonical single-nucleotide polymorphism (canSNP), genotyping, multiple-locus variable- number tandem repeat analysis (MLVA)
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