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JOURNAL OF VETERINARY SCIENCE 15(2): 249~258
Equine hyperimmune serum protects mice against
, Kang-Soon Shin
, Shih-Jon Wang
, Hua Xiang
, Thomas Divers
, Sean McDonough
, James Bowman
, Anne Rowlands
, Bruce Akey
, Hussni Mohamed
, Yung-Fu Chang
Animal Health Diagnostic Center, Departments of Population Medicine and Diagnostic Sciences,
Clinical Sciences, and 5Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA,
Department of Bioscience Technology, Chang Jung Christian University, Tainan 71101, Taiwan R.O.C.
Veterinary Institute, Guangdong Academy of Agricultural Sciences, Guangzhou 510640, China,
Lake Immunogenics Inc., Ontario, NY 14519, USA
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (
) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
is a common cause of nosocomial diarrhea in horses. Vancomycin and metronidazole have been used as standard treatments but are only moderately effective, which highlights the need for a novel alternative therapy. In the current study, we prepared antiserum of equine origin against both
toxins A and B as well as whole-cell bacteria. The toxin-neutralizing activities of the antibodies were evaluated
and the prophylactic effects of
passive immunotherapy were demonstrated using a conventional mouse model. The data demonstrated that immunized horses generated antibodies against both toxins A and B that possessed toxin-neutralizing activity. Additionally, mice treated with the antiserum lost less weight without any sign of illness and regained weight back to a normal range more rapidly compared to the control group when challenged orally with 10
spores 1 day after serum injection. These results indicate that intravenous delivery of hyperimmune serum can protect animals from
challenge in a dose-dependent manner. Hence, immunotherapy may be a promising prophylactic strategy for preventing
infection in horses.
, colitis, equine, immunotherapy
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